Biochemical Introduction To Toxicology
Chemistry
Faculty of Arts and Scıences
First Cycle (Bachelor's Degree)
| Course Unit Title | Course Unit Code | Type of Course Unit | Level of Course Unit | Year of Study | Semester | ECTS Credits |
|---|---|---|---|---|---|---|
| Biochemical Introduction To Toxicology | KIM443 | Elective | Bachelor's degree | 4 | Fall | 3 |
Name of Lecturer(s)
Associate Prof. Dr. Mustafa Oğuzhan KAYA
Learning Outcomes of the Course Unit
1) Learn the definition and scope of biochemical toxicology
2) Learn the ways of entry of toxic substances into the body
3) Learns the transformation of toxic substances by phase I and phase II reactions in the liver
4) Toksik maddelerin ve metabolitlerinin eliminasyon yollarını öğrenir
5) Learn the elimination pathways of toxic substances and their metabolites
6) Learns the biochemical mechanisms of toxicity
Program Competencies-Learning Outcomes Relation
| Program Competencies | |||||||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | ||
| Learning Outcomes | |||||||||||||
| 1 | No relation | High | High | High | High | High | High | High | High | High | High | High | |
| 2 | High | High | High | High | High | High | High | High | High | High | High | High | |
| 3 | High | High | High | High | High | High | High | High | High | High | High | High | |
| 4 | High | High | High | High | High | High | High | High | High | High | High | High | |
| 5 | High | High | High | High | High | High | High | High | High | High | High | High | |
| 6 | High | High | High | High | High | High | High | High | High | High | High | High | |
Mode of Delivery
Face to Face
Prerequisites and Co-Requisites
None
Recommended Optional Programme Components
Biochemistry
Course Contents
Biochemical toxicology: definition and scope, absorption and distribution, toxicokinetics, phase I and phase II reactions of toxicants, comparative toxicology, chemical and environmental factors affecting the metabolism of xenobiotics, elimination of toxicants and their metabolites, toxicant - receptor interactions: basic principles, cholinesterase inhibitors, central nervous system system biotoxicants, the effects of toxicants on oxidative phosphorylation, the effects of toxicants on nucleic acid and protein metabolism, genetic poisons, chemical carcinogenics, trace element toxicity.
Weekly Schedule
1) Biochemical aspects of toxicology2) Biochemical aspects of toxicology
3) DOSE-RESPONSE RELATIONSHIPS
4) DOSE-RESPONSE RELATIONSHIPS
5) FACTORS AFFECTING TOXIC RESPONSES: DISPOSITION
6) FACTORS AFFECTING TOXIC RESPONSES: DISPOSITION
7) FACTORS AFFECTING TOXIC RESPONSES: METABOLISM
8) MIDTERM EXAM
9) FACTORS AFFECTING TOXIC RESPONSES: METABOLISM
10) CHEMICAL AND BIOLOGICAL FACTORS
11) CHEMICAL AND BIOLOGICAL FACTORS
12) TOXIC RESPONSES TO FOREIGN COMPOUNDS
13) TOXIC RESPONSES TO FOREIGN COMPOUNDS
14) BIOCHEMICAL MECHANISMS OF TOXICITY: SPECIFIC EXAMPLES
15) BIOCHEMICAL MECHANISMS OF TOXICITY: SPECIFIC EXAMPLES
16) FINAL EXAM
Recommended or Required Reading
1- John A. Timbrell Principles of Biochemical Toxicology, Fourth Edition [4 ed.] 0849373026, 9780849373022 CRC Press 2008
2- Robert C. Smart, Ernest Hodgson Smart,Molecular and Biochemical Toxicology Molecular and Biochemical Toxicology [4 ed.] 047010211X, 978-0-470-10211-4 Wiley 2008
3- R. A. Goyer (auth.), Robert A. Goyer M.D., M. George Cherian Ph.D. (eds.) Handbook of Experimental Pharmacology 115 Toxicology of Metals: Biochemical Aspects [1 ed.] 978-3-642-79164-2, 978-3-642-79162-8 Springer-Verlag Berlin Heidelberg 1995
Planned Learning Activities and Teaching Methods
1) Lecture
2) Question-Answer
3) Discussion
4) Demonstration
5) Simulation
6) Brain Storming
7) Case Study
8) Problem Solving
Assessment Methods and Criteria
Contribution of Midterm Examination to Course Grade |
40% |
|---|---|
Contribution of Final Examination to Course Grade |
60% |
Total |
100% |
Language of Instruction
Turkish
Work Placement(s)
Not Required