| Course Unit Title | Course Unit Code | Type of Course Unit | Level of Course Unit | Year of Study | Semester | ECTS Credits |
|---|---|---|---|---|---|---|
| Regulation of Gene Expression | BIO424 | Elective | Bachelor's degree | 4 | Spring | 4 |
Name of Lecturer(s)
Associate Prof. Dr. Gülsüm Ebru ÖZER UYAR
Associate Prof. Dr. Canan SEVİMLİ GÜR
Associate Prof. Dr. Sevgi TÜRKER KAYA
Associate Prof. Dr. Yonca YÜZÜGÜLLÜ KARAKUŞ
Assistant Prof. Dr. Zeynep BETTS
Learning Outcomes of the Course Unit
1) Explaining the regulation of gene expression.
2) Listing the mechanisms of the regulation of gene expression.
3) Listing the regulatory mechanisms in gene expression of prokaryotes and eukaryotes.
4) Listing the abnormalities in gene expression.
Program Competencies-Learning Outcomes Relation
| Program Competencies | ||||||||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | ||
| Learning Outcomes | ||||||||||||||
| 1 | Middle | Middle | Middle | Middle | No relation | High | Middle | Middle | Middle | Middle | Middle | Middle | Middle | |
| 2 | High | High | High | High | High | High | No relation | High | High | High | High | High | High | |
| 3 | Middle | Middle | Low | Middle | Middle | No relation | Low | Low | Low | Middle | Middle | Middle | High | |
| 4 | Middle | High | Middle | High | Middle | Middle | High | High | High | High | High | Middle | Middle | |
Mode of Delivery
Face to Face
Prerequisites and Co-Requisites
None
Recommended Optional Programme Components
Not Required
Course Contents
The structure and organization of gene, DNA replication together with repair mechanisms, THe control of gen expression, DNA-binding proteins in gene regulation proteins, genetic recombination mechanisms, molecular genetic mechanisms in gene expression, posttranscriptional control
Weekly Schedule
1) Introduction. The importance of these stages, phases and the control of gene expression2) Fundamentals of transcriptional control in prokaryotes, and the structure of theRNA polymerase promoter
3) Operons of prokaryotic transcription, samples
4) Activation-repression mechanisms in prokaryotes. DNA supercoils
5) Control of gene expression in eukaryotes. transcriptional control
6) In eukaryotes, the promoter, the DNA index elements, based on the formation of the starting complex
7) Transcriptional control working methods
8) Midterm examination/Assessment
9) Mechanisms of activation and repression of transcription in eukaryotes
10) Mechanisms of activation and repression of transcription in eukaryotes
11) Modulation of transcription factors
12) Post-transcriptional control, regulation of the division of RNA
13) the regulation of Handling and stability of RNA
14) the regulation of translation
15) Control of gene expression in tissue-specific expression, development, diseases such as cancer, in terms of compliance and the importance of environmental stresses
16) Final examination
Recommended or Required Reading
Planned Learning Activities and Teaching Methods
1) Lecture
2) Question-Answer
3) Discussion
4) Drill and Practice
5) Problem Solving
Assessment Methods and Criteria
Language of Instruction
Turkish
Work Placement(s)
Not Required