| Course Unit Title | Course Unit Code | Type of Course Unit | Level of Course Unit | Year of Study | Semester | ECTS Credits |
|---|---|---|---|---|---|---|
| Medical Biology | DHF119 | Compulsory | Bachelor's degree | 1 | 6 |
Name of Lecturer(s)
Associate Prof. Dr. Aylin KANLI
Learning Outcomes of the Course Unit
1) 1. Identify the development, structure and function of cell and its subcomponents.
2) 2. Evaluate the biochemical process of the cell.
3) 3. Explain the importance and use of molecular genetics in todays medicine.
4) 4. Assess and understand papers written in the field of molecular genetics.
5) 5. Discuss the methodology of papers written in the field of molecular genetics and state alternative applicable approaches to the given methodology.
6) 6. Clarify how significant molecular biology and how we can utilize molecular biology.
7) 7. Explain what the human molecular biology is based on.
8) 8. Explain how genes are organized in prokaryote, eukaryotes and function of regulatory elements.
9) 9. Explain the mechanisms (transition from DNA to RNA, transition from RNA to protein) that make the information carried by DNA usable
10) 10. Comprehends the cell cycle-proliferation, interphase-mitosis phases, how cell checkpoints work, how cancerization develops and the importance of programmed cell death, the roles of apoptosis, autophagy in cellular life, and defines the stages of cell division in living things.
11) 11. Explain how constitutive and inducible gene expression achieved in organisms
12) 12. Express chromosomes harboring genes causing pathology in human.
13) 13. Distingiush genetic disease caused by monogenic disorders and multifactorial disorders.
14) 14. Clarify all genetic disorders in man with respective mechanisms, chromosomal basis of genetic disorders.
15) 15. Express chromosomal basis of genetic disorders such as diseases caused by anoploidies and mechanism of inheritance and maternal inheritance.
16) 16. Expresses the mutation types and the effects of mutagens.
Program Competencies-Learning Outcomes Relation
| Program Competencies | |||||||
| 1 | 2 | 3 | 4 | 5 | 6 | ||
| Learning Outcomes | |||||||
| 1 | Low | No relation | No relation | No relation | No relation | No relation | |
| 2 | Middle | Low | No relation | No relation | No relation | No relation | |
| 3 | Low | No relation | No relation | No relation | No relation | No relation | |
| 4 | Low | No relation | Low | No relation | No relation | No relation | |
| 5 | No relation | No relation | Low | No relation | No relation | No relation | |
| 6 | Low | No relation | Low | No relation | No relation | No relation | |
| 7 | Low | No relation | No relation | No relation | No relation | No relation | |
| 8 | Low | No relation | Low | No relation | No relation | No relation | |
| 9 | Low | No relation | Low | No relation | No relation | No relation | |
| 10 | Low | No relation | Low | No relation | No relation | No relation | |
| 11 | Low | No relation | Low | No relation | No relation | No relation | |
| 12 | No relation | No relation | Low | No relation | No relation | No relation | |
| 13 | No relation | Low | Low | No relation | No relation | No relation | |
| 14 | Low | No relation | Low | No relation | No relation | No relation | |
| 15 | Low | No relation | Low | No relation | No relation | No relation | |
| 16 | Low | No relation | Low | No relation | No relation | No relation | |
Mode of Delivery
Face to Face
Prerequisites and Co-Requisites
None
Recommended Optional Programme Components
Medical Biology
Course Contents
The Origin and Evolution of Cells; The Molecules of Cells; Cell Membranes; Cell Metabolism and Evolution of Metabolism; Fundamentals of Molecular Biology: Heredity, Genes and DNA, Expression of Genetic Information, Recombinant DNA, Detection of Nucleic Acids and Proteins, Gene Function in Eukaryotes; The Complexity of Eukaryotic Genomes; Chromosomes and Chromatin; The Sequences of Complete Genomes; DNA Replication; DNA Repair; Recombination between Homologous DNA Sequences, DNA Rearrangements; Transcription in Prokaryotes; Regulation of Transcription in Eukaryotes, RNA Processing; Translation of mRNA, Protein Folding and Processing, Regulation of Protein Function, Protein Degradation Nucleus, The Nuclear Envelope and Traffic between the Nucleus and the Cytoplasm, The Nucleolus and rRNA Processing; Protein Sorting and Transport: The Endoplasmic Reticulum, Golgi Apparatus, and Lysosomes; Mitochondria, The Mechanism of Oxidative Phosphorylation, Peroxisomes; The Cytoskeleton and Cell Movement; Cell Cycle and Cell Divisions (Mitosis and Meiosis); Cell Signalling and Intracellular Signalling Pathways Fundamentals of Genetics: Terminology,Mendel’s Laws, Mendelian Genetics; Relations of Genes (Deviations of Mendel’s Ratios); Non-Mendelian Heredity; Modes of Heredity; Chromosomal Aberrations and Examples of Chromosomal Diseases in Man Gene mutations and mutagens Single Gene Diseases in Man
Weekly Schedule
1) 1. The Origin and Evolution of Cells2) 2. Cell Metabolism and Evolution of Metabolism
3) 3. Molecular components of the Cell
4) 4. Cell Membranes
5) The Cytoskeleton and Cell Movement
6) 6. Fundamentals of Molecular Biology: Heredity, Genes and DNA, Expression of Genetic Information, Recombinat DNA, Detection of Nucleic Acids and Proteins, Gene Function in Eukoryotes
7) 7. Genomic Organization and gene regulation in Prokaryotes
8) 8. Genomic Organization and gene regulation in Eukoryotes
9) 9. DNA Replication
10) 10. DNA Damage and Repair Mechanisms
11) 11. Recombination between Homologous DNA Sequences, DNA Rearrangments and Transposons
12) 12. Structure of RNA, RNA types and Processing of RNAs
13) 13. Transcription in Prokaryotes and Eukaryotes and Regulation of Transcription
14) 14. Epigenetic regulation of RNAs
15) 15. Midterm Examination / Assessment
16) 16. Translation, Regulation of Post-Synthesis Protein Function and Protein Degradation
17) 17. Nucleus, Nucleolus and Traffic between the Nucleus and the Cytoplasm
18) 18. Protein Sorting and Transport: The Endoplasmic Reticulum, Golgi Apparatus, and Lysosomes
19) 19. Mitochondria, The Mechanism of Oxidative Phosphorilation, Peroxisomes
20) 20. Cell Cycle and Cell Divisions (Mitosis)
21) 21. Meiosis and Results
22) 22. Cell Signalling
23) 23. Intracellular Signalling Pathways
24) 24. Fundamental of Genetics: Terminology, Mendel's Laws, Mendelian Genetics, Genetic Linkage and Linkage Ratios
25) 25. Relations of Genes (Deviations of Mendel's Ratios) and Non-Mendelian Heredity
26) 26. Modes of Heredity
27) 27. Chromosomal Aberrations and Examples of Chromosomal Diseases in Man
28) 28. Gene mutations and mutagens
29) 29. Single Gene Diseases in Man
30) 30. Final Examination
Recommended or Required Reading
1- Hücre: Moleküler Yaklaşım, Üçüncü Baskı (Çeviri) Çeviri Editörleri: Prof. Dr. Meral SAKIZLI, Prof. Dr. Neşe ATABEY
2- Hücrenin Moleküler Biyolojisi, Dördüncü Baskı (Çeviri) Yazarları: Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walker
3- The Cell: A Molecular Approach, Fifth Edition Authors: Geoffry M. Cooper, Robert E. Hausman
4- Molecular Biology of the Cell, Fourth Edition Authors: Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walker
5- Moleküler Biyolojide Kullanılan Yöntemler Editörler: Prof. Dr. Güler DEMİRKAN, Prof. Dr. Nazlı ARDA
Planned Learning Activities and Teaching Methods
1) Lecture
2) Question-Answer
3) Discussion
4) Self Study
Assessment Methods and Criteria
Contribution of Semester Studies to Course Grade |
40% |
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Contribution of Final Examination to Course Grade |
60% |
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Total | 100% | ||||||||||||||
Language of Instruction
Turkish
Work Placement(s)
Not Required