Extracellular Matrix and Good Manufacturing Practices
Medical Biology
Institute of Health Sciences
Second Cycle (Master's Degree)
| Course Unit Title | Course Unit Code | Type of Course Unit | Level of Course Unit | Year of Study | Semester | ECTS Credits |
|---|---|---|---|---|---|---|
| Extracellular Matrix and Good Manufacturing Practices | TBG520 | Elective | Master's degree | 1 | Spring | 6 |
Name of Lecturer(s)
Associate Prof. Dr. Banu İSKENDER İZGİ
Learning Outcomes of the Course Unit
1) Tells the basic concepts of the extracellular matrix
2) Gives examples to the extracellular matrix components
3) Explains the functions of the extracellular matrix components
4) Knows the recent and potential applications of extracellular matrix
5) Exemplifies the in vitro applications of the extracellular matrix
Program Competencies-Learning Outcomes Relation
| Program Competencies | ||||||||||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | ||
| Learning Outcomes | ||||||||||||||||
| 1 | Middle | Middle | Middle | Middle | Middle | Middle | Low | Middle | High | Middle | Middle | Middle | High | High | Middle | |
| 2 | Middle | High | High | High | High | Middle | Low | Middle | High | Middle | Middle | High | Middle | Middle | Middle | |
| 3 | Middle | High | High | High | High | High | Low | High | High | Middle | Middle | Low | Middle | Middle | Middle | |
| 4 | Middle | Low | Low | Middle | Low | Middle | Low | Middle | High | High | High | High | Middle | Middle | Middle | |
| 5 | Middle | Low | Middle | Low | Low | Middle | Middle | Middle | Middle | Low | Middle | Middle | Middle | High | Middle | |
Mode of Delivery
Face to Face
Prerequisites and Co-Requisites
None
Recommended Optional Programme Components
Biomolecules
Course Contents
The components of the extracellular matrix, hierarchical organisation of the structure and the in vitro as well as in vivo effects on the cellular biological functions will be the main themes. The roles of the extracellular matrix on normal and pathological processes will be examined in the context of recent literature and clinical studies.
Weekly Schedule
1) Introduction to Extracellular Matrix Biology-Definitions2) Collagen Structure and Organisation
3) Fibronectin Structure and Organisation
4) Vitronectin Structure and Organisation
5) Laminin Structure and Organisation
6) Hyaluronan Structure and Organisation
7) The Concept of Niche and Matrix Modelling
8) Cell Derivation and Extracellular Matrix
9) Good Manufacturing Practices in Cell Culture
10) Extracellular Matrix in Good Manufacturing Practices I
11) Extracellular Matrix in Good Manufacturing Practices II
12) Extracellular Matrix in Good Manufacturing Practices III
13) Extracellular Matrix Components in Tumour Microenvironment
14) Modelling Tumour Microenvironment in vitro
Recommended or Required Reading
1- Structure and Function of the Extracellular Matrix-Bela Suki- Academic Press 2021
2- Tumor Microenvironment-Alexander Birbrair-Springer
Planned Learning Activities and Teaching Methods
1) Lecture
2) Question-Answer
3) Discussion
4) Self Study
Assessment Methods and Criteria
Contribution of Semester Studies to Course Grade |
40% |
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Contribution of Final Examination to Course Grade |
60% |
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Total | 100% | ||||||||||||||
Language of Instruction
Turkish
Work Placement(s)
Not Required