Population Genetic and Molecular Evolution
Medical Genetics and Molecular Biology
Institute of Health Sciences
Second Cycle (Master's Degree)
| Course Unit Title | Course Unit Code | Type of Course Unit | Level of Course Unit | Year of Study | Semester | ECTS Credits |
|---|---|---|---|---|---|---|
| Population Genetic and Molecular Evolution | MBG509 | Elective | Master's degree | 1 | Fall | 3 |
Name of Lecturer(s)
Prof. Dr. Naci ÇİNE
Prof. Dr. Hakan SAVLI
Learning Outcomes of the Course Unit
1) Comprehending the mechanisms of evolution.
2) Calculating genetic variation.
3)Understanding how to contribute to evolutionary changes in genetic variation
4Understanding the basic mechanisms of inheritance.
5) Calculating the probability of a certain genetic diseases.
6) Analyzing recent studies on human health.
Program Competencies-Learning Outcomes Relation
| Program Competencies | ||||||
| 1 | 2 | 3 | 4 | 5 | ||
| Learning Outcomes | ||||||
| 1 | No relation | No relation | No relation | No relation | No relation | |
Mode of Delivery
Face to Face
Prerequisites and Co-Requisites
None
Recommended Optional Programme Components
Medical genetics
Course Contents
This course equips candidates with in-depth knowledge on subjects such as; genetic diversity, mechanisms of evolution, calculation of Genetic variation, mechanisms of heredity, and the probability of a certain genetic diseases,mutation, recombination, genom mapping and genom projects. Analysis of recent scientific studies population genetics and evolution are also among the scopes of this course.
Weekly Schedule
1) Population genetics and genetic diversity2) Dynamics of genes in populations: natural selection, genetic drift, effective population size
3) Mutation, recombination, due to genes (linkage) and the genetic disparity
4) HW equilibrium and deviations from Hardy Weinberg principle: the same lineageinbreeding, non-random mating, population fragmentation and gene flow
5) Nucleotide sequences and evolutionary change: Nucloitide changes, amino acid changes: exchange rate and exchange mechanisms
6) Natural selection models
7) Molecular population genetics
8) Midterm examination/Assessment
9) Population genetics applications (literature studies)
10) Gene duplication, exon shuffling, transposition, and evolution
11) The evolution of genome
12) Molecular evolution and phylogenetic
13) Quantitative genetics
14) Maps of the genome and human genome project
15) Evolution in human health applications: Antibiotic resistance of HIV, Huntington's disease, cystic fibrosis and muscular distrophy
16) Final examination
Recommended or Required Reading
1- Population, Evolution and Birth Control: A College of Controversial Ideas, Garrett Hardin
2- Thompson&Thompson Tıbbi Genetik (Thompson&Thompson Genetics in Medicine)
3- Genetics in Practice / Jo Hayden
4- The Genetic Family History / Robin L. Bennett
5- Moleküler Genetiğin Esasları / Doç. Dr. H. Ümit Lüleyap
6- Population, Evolution and Birth Control: A College of Controversial Ideas, Garrett Hardin
7- Population, Evolution and Birth Control: A College of Controversial Ideas, Garrett Hardin
8- Population, Evolution and Birth Control: A College of Controversial Ideas, Garrett Hardin
9- Population, Evolution and Birth Control: A College of Controversial Ideas, Garrett Hardin
10- Population, Evolution and Birth Control: A College of Controversial Ideas, Garrett Hardin
11- Population, Evolution and Birth Control: A College of Controversial Ideas, Garrett Hardin
Planned Learning Activities and Teaching Methods
1) Lecture
2) Question-Answer
3) Discussion
4) Group Study
5) Lab / Workshop
Assessment Methods and Criteria
Contribution of Semester Studies to Course Grade |
40% |
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Contribution of Final Examination to Course Grade |
60% |
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Total | 100% | |||||||||||
Language of Instruction
Turkish
Work Placement(s)
Not Required