Organic Reaction Mechanism

Learning Outcomes of the Course Unit

1) Understand molecular structure and reactivity, the first look at the general rules in writing Organic Reaction Mechanism
2) Gain information about structure and reactivity in nucleophilic substitution reactions, carbocations, nucleophiles, leaving groups, solvent effect, SN1 and SN2 reaction mechanisms, nucleophilic substitution on the carbonyl group
3) Gain information about structure and reactivity in elimination reactions, carbocations, nucleophiles, leaving groups, solvent effect, E1, E2 and E1cB reaction mechanisms, comparison of substitution and elimination
3) Select apropriate reagent and solvent
4) Learn electrophilic aromatic substitution reactions, halogenation, nitration, sulphonation, alkylation and acylation reaction mechanisms, ortho, meta and para directives, orientation of second and future substituents, nucleophilic aromatic substitution
5) Learn electrophilic addition reactions, alkene and alkyne chemistry, addition to dienes, stereochemistry of addition, stereoselectivity and regioselectivity, epoxidation, hydroboration, osmilation, ozonation, etc.
6) Understand nucleophilic addition reactions, addition of water and alcohol, semi-acetal and acetals, cyanohydrin, imine and enamine formation, hydrazine addition, conjugated nucleophile addition to alpha and beta-unsaturated aldehydes and ketones, addition of organometallic reagents, Grignard, Wittig etc.
7) Gain information about condensation reactions, aldol and cross-aldol reactions, Mannich reaction, Micheal reaction, Claisen, Perkin, Reformatsky, Stobbe, Dieckmann, Darzens, Knoevanagel reactions, enolates, conjugated addition to enolates
8) Learns rearrangement reactions, alkyl and aryl substitution on carbon, oxygen and nitrogen, Beckmann, Hofmann, Favorski, Baeyer-Villiger, Schmidt, benzilic acid reactions, hydride transfer, Cannizzarro, Meervwein-Ponndorrf-Verley reactions
10) Radikalik reaksiyonlar, radikal kararlılığı ve reaksiyon vermelerini analiz eder
11) Obtains basic knowledge through asymmetric synthesis
12) .Understand pericyclic reactions, Dies Alders additions
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