| Course Unit Title | Course Unit Code | Type of Course Unit | Level of Course Unit | Year of Study | Semester | ECTS Credits |
|---|---|---|---|---|---|---|
| Epigenetics | TBG711 | Elective | Doctorate degree | 2 | Fall | 6 |
Name of Lecturer(s)
Prof. Dr. Emel ERGÜL
Prof. Dr. Murat KASAP
Learning Outcomes of the Course Unit
1) Define basic concepts in epigenetics
2) Explain formation of the heterochromatin
3) Explain epigenetic regulation of inheritance
4) Discuss dosage compensation
5) Discuss the role of DNA methylation and genomic imprinting in germline and pluripotent stem cells, in nukleer transplantation, in the reprogramming of the genome, and in cancer formation
Program Competencies-Learning Outcomes Relation
| Program Competencies | ||||||||||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | ||
| Learning Outcomes | ||||||||||||||||
| 1 | High | High | High | High | High | High | High | High | High | High | High | High | High | High | High | |
| 2 | High | High | High | High | High | High | High | High | High | High | High | High | High | High | High | |
| 3 | High | High | High | High | High | High | High | High | High | High | High | High | High | High | High | |
| 4 | High | High | High | High | High | High | High | High | High | High | High | High | High | High | High | |
| 5 | High | High | High | High | High | High | High | High | High | High | High | High | High | High | High | |
Mode of Delivery
Face to Face
Prerequisites and Co-Requisites
None
Recommended Optional Programme Components
6311030 Gene Regulation
Course Contents
This course will give in-depth knowledge about History of Epigenetics, Overview and Concepts, Heterochromatin Formation, RNAi and Heterochromatin Assembly, Chromatin Modifications, Histon Variants, Epigenetic regulation of Inheritance, Dosage Compensation, DNA methylation and genomic imprinting, Germline and Pluripotent stem cells, Nukleer transplantation and the reprogramming of the genome, Epigenetic Determinants in Cancer.
Weekly Schedule
1) Clues from Genetics and Devolopment2) Reprograming the cell fate
3) Chromatin Modification
4) Mechanism of Chromatin modification
5) From Gene to Chromosome repression
6) Histone variants and Epigenetics
7) Silencing of Unsynapsed Chromosomes in the mouse
8) Dosage Compensation in Mamals
9) Stability of X inaktivation in Somatic Cells
10) Xist RNA and gene silencing
11) DNA metilasyonu
12) DNA methilation, Mutation and Chromosomal Stability
13) Mechanism of cell memory
14) Genomic İmpring
15) Pluripotent Stem Cells
16) Epigenetiv and Disease
Recommended or Required Reading
1- Epigenetics, Allis C, Reinberg D
2- Thompson and Thomson
3- The Cell
Planned Learning Activities and Teaching Methods
1) Lecture
2) Question-Answer
3) Discussion
4) Drill and Practice
5) Brain Storming
6) Self Study
Assessment Methods and Criteria
Contribution of Midterm Examination to Course Grade |
40% |
|---|---|
Contribution of Final Examination to Course Grade |
60% |
Total |
100% |
Language of Instruction
Turkish
Work Placement(s)
Not Required