Molecular Stem Cell Biology
Stem Cell and Tissue Regeneration
Institute of Health Sciences
Third Cycle (Doctorate Degree)
| Course Unit Title | Course Unit Code | Type of Course Unit | Level of Course Unit | Year of Study | Semester | ECTS Credits |
|---|---|---|---|---|---|---|
| Molecular Stem Cell Biology | KHT646 | Compulsory | Doctorate degree | 1 | Fall | 6 |
Name of Lecturer(s)
Associate Prof. Dr. Gökhan DURUKSU
Learning Outcomes of the Course Unit
1) Learns basic methods in molecular researches.
2) Gaining the knowledge on intracellular role of telomeres
3) Gaining critical view on the culture of stem cells
4) Discuss the molecular interactions of stem cells.
Program Competencies-Learning Outcomes Relation
| Program Competencies | |||||||
| 1 | 2 | 3 | 4 | 5 | 6 | ||
| Learning Outcomes | |||||||
| 1 | No relation | No relation | No relation | No relation | No relation | No relation | |
| 2 | No relation | No relation | No relation | No relation | No relation | No relation | |
| 3 | No relation | No relation | No relation | No relation | No relation | No relation | |
| 4 | No relation | No relation | No relation | No relation | No relation | No relation | |
Mode of Delivery
Face to Face
Prerequisites and Co-Requisites
None
Recommended Optional Programme Components
Not Required
Course Contents
Stem cell, organogenesis and tissue regeneration relationship, biofactors and micro-environment, stem cell differentiation and intracellular signaling pathways, the role of epigenetics in differentiation, back programming and recovery of pluripotent properties, pluripotent stem cell lines, cultures and differentiation
Weekly Schedule
1) Basic concepts of cell culture and differentiation2) Stem cell, organogenesis and tissue regeneration
3) Stem cell, organoid culture and pluripotency
4) Microenvironment
5) Co-culture techniques in differentiation
6) Receptors
7) Intracellular signaling pathways
8) Midterm examination/Assessment
9) Stem cell differentiaton
10) Stem cell differentiation and scaffolds
11) Differentiation and epigenetics
12) Reprogramming and pluripotent properties
13) Generation of iPSCs and epigenetics
14) iPSCs cell lines culture and differentiation
15) Programming and transdifferentiation
16) Final examination
Recommended or Required Reading
1- Culture of Human Stem Cells.R. Ian Freshney, Glyn N. Stacey, Jonathan M. Auerbach. 2007, Wiley-Blackwell ISBN: 978-0-470-05246-4
2- Stem cells: scientific progress and future research directions. National Institutes of Health. November 2004, University Press of the Pacific. ISBN: 978-1-4102-1896-4
3- Biology of Stem Cells and the Molecular Basis of the Stem State. Dov Zipori, 2009, Humana Press, Heidelberg, ISBN: 978-1-60761-130-1
Planned Learning Activities and Teaching Methods
1) Lecture
2) Question-Answer
3) Discussion
4) Brain Storming
5) Case Study
Assessment Methods and Criteria
Contribution of Semester Studies to Course Grade |
50% |
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Contribution of Final Examination to Course Grade |
50% |
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Total | 100% | |||||||||||
Language of Instruction
Turkish
Work Placement(s)
Not Required