Molecular Genetics of Stem Cell
Stem Cell and Tissue Regeneration
Institute of Health Sciences
Third Cycle (Doctorate Degree)
| Course Unit Title | Course Unit Code | Type of Course Unit | Level of Course Unit | Year of Study | Semester | ECTS Credits |
|---|---|---|---|---|---|---|
| Molecular Genetics of Stem Cell | KHT650 | Elective | Doctorate degree | 1 | Fall | 5 |
Name of Lecturer(s)
Assistant Prof. Dr. Zehra Seda HALBUTOĞULLARI
Learning Outcomes of the Course Unit
1) Learning the genetic properties of stem cells and gene expression profiles.
2) Understanding signal pathways and molecular mechanisms in stem cells.
3) To learn about gene therapy and its applications in stem cells.
Program Competencies-Learning Outcomes Relation
| Program Competencies | |||||||
| 1 | 2 | 3 | 4 | 5 | 6 | ||
| Learning Outcomes | |||||||
| 1 | No relation | No relation | No relation | No relation | No relation | No relation | |
| 2 | No relation | No relation | No relation | No relation | No relation | No relation | |
| 3 | No relation | No relation | No relation | No relation | No relation | No relation | |
Mode of Delivery
Face to Face
Prerequisites and Co-Requisites
None
Recommended Optional Programme Components
Advanced Cell and Stem Cell Biology
Course Contents
Genetic structure of stem cell, epigenetic changes in stem cells, reprogramming in stem cells, genetic basis of self-renewal, genetic basis of stem cell signal transduction pathways and current genetic treatment approaches in stem cells.
Weekly Schedule
1) Introduction to the genetic structure of the stem cell2) Embryonic stem cell genetics and receptor genes
3) Gene expression in embryonic stem cells, adult stem cells and cancer stem cells
4) Genetics of Notch pathway in stem cells
5) WNT / catenin pathway in stem cells
6) TGF / BMP and FGF pathway in stem cells
7) Submission of assignment
8) Quiz
9) Genetic basis of pluripotency
10) Genetic mechanism of reprogramming
11) Embryonic stem cell against induced pluripotent stem cell
12) Epigenetic changes in stem cells
13) The use of genetically modified stem cells in experimental gene therapy
14) Genetic analysis applications in stem cells
15) Future targets and applications in stem cell genetics
16) Final exam
Recommended or Required Reading
1- Thompson & Thompson Genetics in Medicine. Ed. Roderick R. McInnes, Huntington F. Willard, Robert L. Nussbaum, 2015, Elsevier, ISBN: 978-1-437-70696-3
2- Lewin's GENES X. Ed. Jocelyn Krebs, Elliott Goldstein, Stephen Kilpatrick, 2009, Jones & Bartlett Publishers. ISBN-13: 978-0-7637-6632-0
Planned Learning Activities and Teaching Methods
1) Lecture
2) Lecture
3) Lecture
4) Lecture
5) Lecture
6) Lecture
7) Question-Answer
8) Question-Answer
9) Question-Answer
10) Question-Answer
11) Question-Answer
12) Question-Answer
13) Discussion
14) Discussion
15) Discussion
16) Discussion
17) Discussion
18) Discussion
19) Lab / Workshop
20) Lab / Workshop
21) Lab / Workshop
22) Lab / Workshop
23) Lab / Workshop
24) Lab / Workshop
Assessment Methods and Criteria
Contribution of Semester Studies to Course Grade |
60% |
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Contribution of Final Examination to Course Grade |
40% |
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Total | 100% | ||||||||||||||
Language of Instruction
Turkish
Work Placement(s)
Not Required