| Course Unit Title | Course Unit Code | Type of Course Unit | Level of Course Unit | Year of Study | Semester | ECTS Credits |
|---|---|---|---|---|---|---|
| Cancer Stem Cell | KHT658 | Compulsory | Doctorate degree | 2 | Fall | 6 |
Name of Lecturer(s)
Associate Prof. Dr. Gülçin GACAR
Learning Outcomes of the Course Unit
1) Have knowledge about Stem cell microenvironment
2) Follows the recent advances about cancer stem cell hypothesis
3) Have knowledge about tumor stem cells and malignant cells
4) Knows characterization of cancer stem cells
5) Knows and understands cancer stem cell pathways (Hedgehog/Gli, Notch signaling pathways, TGF-Beta and Wnt: differentiation factors and epigenetic modulation in normal and malignant stem cells)
6) Knows the role of PTEN in cancer with hematopoietic and intestinal stem cells
Program Competencies-Learning Outcomes Relation
| Program Competencies | |||||||
| 1 | 2 | 3 | 4 | 5 | 6 | ||
| Learning Outcomes | |||||||
| 1 | No relation | No relation | No relation | No relation | No relation | No relation | |
| 2 | No relation | No relation | No relation | No relation | No relation | No relation | |
| 3 | No relation | No relation | No relation | No relation | No relation | No relation | |
| 4 | No relation | No relation | No relation | No relation | No relation | No relation | |
| 5 | No relation | No relation | No relation | No relation | No relation | No relation | |
| 6 | No relation | No relation | No relation | No relation | No relation | No relation | |
Mode of Delivery
Face to Face
Prerequisites and Co-Requisites
None
Recommended Optional Programme Components
The Cell Cycle and Control System
Course Contents
Stem cell and cancer; cancer stem cell hypothesis; tumor stem cells and malignant cells; stem cell microcirculation; characterization of cancer stem cells; cancer stem cell pathways (Hedgehog/Gli, Notch signaling pathways, TGF-Beta and Wnt: differentiation factors and epigenetic modulation in normal and malignant stem cells); the role of PTEN in cancer with hematopoietic and intestinal stem cells; transcription factors in hematopoietic cancer stem cells; stem cell chromatin pattern and DNA hypermethylation; plasticity in multipotent tumor stem cells; sleep tumor cells and metastasis; angiogenesis and neurogenesis in tumor; Role of microRNAs in stem cells and cancer stem cells; strategies for destroying cancer stem cells; Repair mechanisms in stem cells and conversion to cancer stem cells.
Weekly Schedule
1) Stem Cells and Cancer2) The Cancer Stem Cell Hypothesis
3) Tumor Stem Cells and Malignant Cells
4) The Stem Cell Niche (Mesenchymal Stem Cell in Tumor Stroma)
5) Characterization of Cancer Stem Cells
6) Targeting Cancer Stem Cell Pathways (Hedgehog/GLI Signaling in Cancer, Targeting the Notch Signaling Pathway in Cancer Stem Cells, TGF-beta and Wnt in Normal and Malignant Stem Cells: Differentiating Agents and Epigenetic Modulation)
7) PTEN in Hematopoietic and Intestinal Stem Cells and Cancer, Transcription Factors in Cancer Stem Cells of the Hematopoietic Lineage
8) Midterm Exam/Assessment
9) Stem Cell Chromatin Patterns and DNA Hypermethylation
10) Plasticity Underlying Multipotent Tumor Stem Cells
11) Tumor Dormancy and Metastasis
12) Angiogenesis and Neurogenesis in Tumors
13) MicroRNAs in Stem Cell and Cancer Stem Cells
14) Strategies to Eliminate Cancer Stem Cells
15) DNA Repair in Stem Cell Mantenance and Conversion to Cancer Stem Cells
16) Final Examination
Recommended or Required Reading
1- Stem Cells and Cancer. Rebecca G. Bagley, MS. Beverley A. Teicher, PhD. Humana Press, 2009. ISBN: 978-1-60327-932-1
2- Cancer Stem Cells. Identification and Targets. Sharmila Bapat. Wiley, 2009. ISBN: 978-0-470-12201-3
3- Principles of Clinical Cancer Genetics. Daniel C. Chung. Daniel A. Haber.Springer,2010. ISBN: 978-0-387-93844-8.
4- Cancer Stem Cells. William L. Farrar. Cambridge University Press, 2010. ISBN: 978-0-521-89628-3.
Planned Learning Activities and Teaching Methods
1) Lecture
2) Question-Answer
3) Discussion
4) Drill and Practice
5) Group Study
6) Simulation
7) Brain Storming
8) Case Study
9) Lab / Workshop
10) Self Study
11) Problem Solving
12) Project Based Learning
Assessment Methods and Criteria
Contribution of Semester Studies to Course Grade |
40% |
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Contribution of Final Examination to Course Grade |
60% |
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Total | 100% | |||||||||||
Language of Instruction
Turkish
Work Placement(s)
Not Required