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Course Unit Title | Course Unit Code | Type of Course Unit | Level of Course Unit | Year of Study | Semester | ECTS Credits |
---|---|---|---|---|---|---|
Cellular Senescente, Death and Immortalization | KHT624 | Elective | Doctorate degree | 2 | Fall | 5 |
Associate Prof. Dr. Gökhan DURUKSU
1) Understanding of basic principles of regeneration in human tissues after the injury.
Program Competencies | |||||||
1 | 2 | 3 | 4 | 5 | 6 | ||
Learning Outcomes | |||||||
1 | No relation | No relation | No relation | No relation | No relation | No relation |
Face to Face
None
Not Required
In the advanced ages of organisms, the regeneration of damaged tissues slows down along with the decrease in both number and growth rate of adult stem cells. This phenomenon, called as senescence, is often encountered at cellular levels in vitro culture conditions. It affects stem cells rapidly, and causes to display very different cellular properties than their initial states following isolation. The stages and molecular mechanisms of this process developed differently in human and animal cells is the main subject of this course. Telomere biology of stromal and stem cells and its regulation will be examined in this context. Stages of biological aging process independent of telomeres, cell cycle and effects of stress on cells are included in the course syllabus. Immortalization of cells after long term culture will be mentioned in details during the term, and approaches for the production of immortal cell lines will be discussed. The relationship of adult stem cells with stroma and cancer cells will be discussed.
1- Stem cells: scientific progress and future research directions. National Institutes of Health. November 2004, University Press of the Pacific. ISBN: 978-1-4102-1896-4
2- Culture of Human Stem Cells.R. Ian Freshney, Glyn N. Stacey, Jonathan M. Auerbach. 2007, Wiley-Blackwell ISBN: 978-0-470-05246-4
1) Lecture
2) Question-Answer
3) Discussion
4) Drill and Practice
5) Self Study
Contribution of Midterm Examination to Course Grade |
50% |
---|---|
Contribution of Final Examination to Course Grade |
50% |
Total |
100% |
Turkish
Not Required